Clostridium perfringens is a large,spore-forming, gram-positive, nonmotile rod with square ends.
-It is commonly found in the environment and intestines.
-It produces α-toxin, a phospholipase, which causes hemolysis, tissue destruction, and shock.
-It can cause wound infections, soft tissue infections, and gas gangrene
-knife or gunshot wounds, vehicular accident wounds, surgical wounds are particularly susceptible to this bacteria
Symptoms & Signs
Sudden onset of excruciating pain at the affected site, brawny edema, tissue death, foul-smelling serosanguineous discharge, blisters with clear to purplish fluid, gas bubbles, crepitance, fever, hypotension, shock, and multiorgan failure
Diagnosis: clinical history, physical examination, surgical exploration,
Gram’s staining, and histopathologic examination. Biopsy shows gram-positive or gram-variable rods and a paucity of leukocytes. Radiographs may show gas bubbles in the tissues
Gas gangrene is an emergency and requires immediate surgical debridement (excision of all devitalized tissue); administration of penicillin and clindamycin for 10–14 days
Hyperbaric oxygen therapy is controversial .
- What is the most effective method of prevention of gas gangrene? Surgical debridement of traumatic injuries
- What is the most common adverse effect of HBO treatment? Middle ear barotrauma