Medications which cause liver injury

Many drugs can harm the liver. Important associations given below:

Acute hepatocellular injury: Acetaminophen, Isoniazid

Cholestatic injury: Contraceptive steroids, Chlorpromazine

Granulomatous hepatitis: Allopurinol, phenylbutazone,sulfonamides

Chronic hepatitis: methotrexate, nitrofurantoin, methyldopa

Neoplastic lesions: oral contraceptive steroids

Angiosarcoma: Vinyl chloride, thorotrast

Cirrhosis: Amiodarone

Fulminant hepatitis: Halothane

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