Staphylococcal toxic shock syndrome

Staphylococcal toxic shock syndrome (TSS) is a toxin-mediated clinical illness characterized by rapid onset of fever, diffuse macular rash, hypotension, and multiorgan system involvement. 

-associated with tampon use, S aureus colonization of nasopharynx, vagina, rectum, wounds, abscesses 

-Symptoms are due to the production and release of exotoxins by S.aureus

Symptoms & Signs 

-Tongue is usually reddened (Strawberry tongue) 

-Subconjuntival hemorrhages 

-Fever, vomiting, watery diarrhea 

-Diffuse macular rash followed by desquamation particularly on palms and soles 

Diagnosis: Blood cultures are negative in most cases because symptoms are due to the effects of the toxin; wound cultures show S.aureus  

Treatment: Treatment of shock, antibiotic therapy, Removal of sources of toxin (eg, removal of tampon, drainage of abscess), surgical debridement 

Staph TSS vs Strep TSS: Unlike Staph TSS, Strep TSS generally lack a rash, have bacteremia and have an associated soft-tissue infection 

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